The Handbook of Dynamic Data Driven Applications Systems establishes an authoritative reference of DDDAS, pioneered by Dr. Darema and the co-authors for researchers and practitioners developing DDDAS technologies. Beginning with general concepts and history of the paradigm, the text provides 32 chapters by leading experts in10 application areas to enable an accurate understanding, analysis, and control of complex systems; be they natural, engineered, or societal: Earth and Space Data Assimilation Aircraft Systems Processing Structures Health Monitoring Biological Data Assessment Object and Activity Tracking Embedded Control and Coordination Energy-Aware Optimization Image and Video Computing Security and Policy Coding Systems Design The authors explain how DDDAS unifies the computational and instrumentation aspects of an application system, extends the notion of Smart Computing to span from the high-end to the real-time data acquisition and control, and manages Big Data exploitation with high-dimensional model coordination.