混合性结缔组织病科室学习
早期得概念(70年代)
Sharp等1972年首先报道了一组血清中有抗RNP抗体得SLE,SSc与PM重叠得病例,并认为就是一种新得风湿性疾病,称之为MCTD。这些病人肾脏与肺损害相对少,对糖皮质激素疗反应好。
Mixed Connective Tissue Disease (MCTD)
Generalized CT disorder characterized by presence of anti-RNP with some clinical features of SLE, SSc, & PMIncidence、 1/100000Peak incidence: 15-25 yearsFemale to male ratio: 10 to 1