as for the moran index, it is criticall depend on the weight , the weight can be differ on different scale, it can be binary, or it can be based on the distance. the distance maybe the geo distance or the economic and social distance.
to be clear:
1 moran is only a index, it is based on spatial weight
2. You can derive the spatial weight as you like , it can based on the coordinates or based on the trade volume of interregion variables, such as the heighway distance.
hope this chan help you.