摘要翻译:
这篇手稿使用统计力学的方法来研究粘附,通过MOCA蛋白,对细胞运动的影响。MOCA蛋白调节细胞-细胞粘附,我们探索它在细胞运动中的潜在作用。我们提出了一系列运动的统计描述来表征细胞的运动,并发现MOCA影响细胞运动的统计场景。特别地,我们观察到MOCA增强了关节运动的趋势,抑制了超扩散,并降低了细胞的整体运动。这些事实与细胞在不太紧密的环境中移动得更快的假设是一致的。此外,我们观察到,在这里所研究的所有情况下,速度分布尾都比Maxwell-Boltzmann所预测的长,表明细胞运动比液体运动更复杂。
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英文标题:
《Non-Maxwellian velocity distribution and anomalous diffusion of {\it in
vitro} kidney cells》
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作者:
L. Diambra, L. C. Cintra, D. Schubert, and L. da F. Costa
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最新提交年份:
2005
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分类信息:
一级分类:Quantitative Biology 数量生物学
二级分类:Cell Behavior 细胞行为
分类描述:Cell-cell signaling and interaction; morphogenesis and development; apoptosis; bacterial conjugation; viral-host interaction; immunology
细胞-细胞信号传导及相互作用;形态发生和发育;细胞凋亡;细菌接合;病毒-宿主相互作用;免疫学
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一级分类:Physics 物理学
二级分类:Other Condensed Matter 其他凝聚态物质
分类描述:Work in condensed matter that does not fit into the other cond-mat classifications
在不适合其他cond-mat分类的凝聚态物质中工作
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一级分类:Quantitative Biology 数量生物学
二级分类:Other Quantitative Biology 其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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一级分类:Quantitative Biology 数量生物学
二级分类:Subcellular Processes 亚细胞过程
分类描述:Assembly and control of subcellular structures (channels, organelles, cytoskeletons, capsules, etc.); molecular motors, transport, subcellular localization; mitosis and meiosis
亚细胞结构(通道、细胞器、细胞骨架、囊膜等)的组装和控制;分子马达;转运;亚细胞定位;有丝分裂和减数分裂
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英文摘要:
This manuscript uses a statistical mechanical approach to study the effect of the adhesion, through MOCA protein, on cell locomotion. The MOCA protein regulates cell-cell adhesion, and we explore its potential role in the cell movement. We present a series of statistical descriptions of the motion in order to characterize the cell movement, and found that MOCA affects the statistical scenario of cell locomotion. In particular, we observe that MOCA enhances the tendency of joint motion, inhibits super-diffusion, and decreases overall cell motion. These facts are compatible with the hypothesis that the cells move faster in a less cohesive environment. Furthermore, we observe that velocity distribution tails are longer than those predicted by Maxwell-Boltzmann in all cases studied here, indicating that cell movement is more complex than that of a liquid.
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PDF链接:
https://arxiv.org/pdf/q-bio/0503013