摘要翻译:
所有已知的生命形式都建立在一个相互交织的反馈循环的层次之上,在空间、时间和能量尺度的级联上运作。最基本的环是连接DNA和蛋白质的环。例如,在遗传网络中,DNA基因以蛋白质的形式表达,蛋白质可能结合在相同的基因附近,从而控制它们自己的表达。在这种分子类型的自我参照中,信息从DNA序列映射到蛋白质,然后再映射到DNA。存在着多种动态的DNA-蛋白质自参照环,本文的目的是讨论DNA与蛋白质之间来回映射的某些几何和物理方面。讨论提出了关于DNA和蛋白质作为自指物质的本质的基本问题,这些问题在一个简单的玩具模型中得到了检验。
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英文标题:
《The self-referring DNA and protein: a remark on physical and geometrical
aspects》
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作者:
Tsvi Tlusty
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最新提交年份:
2018
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分类信息:
一级分类:Quantitative Biology 数量生物学
二级分类:Other Quantitative Biology 其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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一级分类:Physics 物理学
二级分类:Biological Physics 生物物理学
分类描述:Molecular biophysics, cellular biophysics, neurological biophysics, membrane biophysics, single-molecule biophysics, ecological biophysics, quantum phenomena in biological systems (quantum biophysics), theoretical biophysics, molecular dynamics/modeling and simulation, game theory, biomechanics, bioinformatics, microorganisms, virology, evolution, biophysical methods.
分子生物物理、细胞生物物理、神经生物物理、膜生物物理、单分子生物物理、生态生物物理、生物系统中的量子现象(量子生物物理)、理论生物物理、分子动力学/建模与模拟、博弈论、生物力学、生物信息学、微生物、病毒学、进化论、生物物理方法。
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英文摘要:
All known life forms are based upon a hierarchy of interwoven feedback loops, operating over a cascade of space, time and energy scales. Among the most basic loops are those connecting DNA and proteins. For example, in genetic networks, DNA genes are expressed as proteins, which may bind near the same genes and thereby control their own expression. In this molecular type of self-reference, information is mapped from the DNA sequence to the protein and back to DNA. There is a variety of dynamic DNA-protein self-reference loops, and the purpose of this remark is to discuss certain geometrical and physical aspects related to the back and forth mapping between DNA and proteins. The discussion raises basic questions regarding the nature of DNA and proteins as self-referring matter, which are examined in a simple toy model.
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PDF链接:
https://arxiv.org/pdf/1804.03430