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2022-03-07
摘要翻译:
生命的起源是最大的谜团之一。合成DNA的机制与生命的化学起源是同义的,理论已经沿着许多推理路线发展起来,但解决所有要求仍然是一个挑战,例如定义一个客观的路径来产生编码的核苷酸序列,如腺嘌呤和胸腺嘧啶,鸟嘌呤和胞嘧啶。本文提出了DNA起源的新理论。该理论基于三条实验证据和DNA核苷酸与类固醇激素之间结构对称性的一致性,并引入了一个新的概念,即在一个由交错的四环结构组成的统一复合物中同时合成DNA的结构和功能特征,类固醇分子形成反应容器,充当共酶构建块。新的理论表明DNA核苷酸密码的建立是最早的合成步骤之一。此外,由于在一个统一的复合物中结构和功能特征的分子间合成,存在一个高潮过程步骤,即启动DNA和类固醇结构,随后触发复制和转录,以及蛋白质翻译,从而导致生命功能的瞬时释放。
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英文标题:
《Intermolecular Enzymatic Encoding of Nucleic Acid, Steroid Complexes: A
  New Theory on the Chemical Origin of Life Based on Evidence of Structural
  Symmetry》
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作者:
Charles D. Schaper
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最新提交年份:
2020
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分类信息:

一级分类:Quantitative Biology        数量生物学
二级分类:Other Quantitative Biology        其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要:
  The origin of life is one of the greatest mysteries. The mechanism for the synthesis of DNA is synonymous with the chemical origin of life, and theories have been developed along many lines of reasoning, but resolving all requirements remains a challenge, such as defining an objective path to produce sequences of encoded nucleotides paired as adenine to thymine and guanine to cytosine. Here, a new theory for the origin of DNA is presented. The theory is based upon three lines of experimental evidence and agreement of structural symmetry between DNA nucleotides and steroid hormones, and introduces a new concept of synthesizing both structural and functional characteristics of DNA at the same time within a single unified complex of interleaved tetra-ringed structures, steroid molecules which form reaction vessels that serve as co-enzymatic building blocks. The new theory indicates that the establishment of the DNA nucleotide code is among the very first synthesis steps. Moreover, as a consequence of the intermolecular synthesis of both structural and functional characteristics within a unified complex, there is a culminating process step that sets forth in motion both DNA and the steroid structures that subsequently trigger replication and transcription, as well as protein translation, thereby resulting in the instantaneous release of life function.
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PDF链接:
https://arxiv.org/pdf/2006.06429
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