摘要翻译：
在上个世纪，由于工业、职业、医疗和家庭用途造成的污染增加，全球环境中的汞含量增加了两倍。谷胱甘肽已知是负责汞排泄的主要物质（我们参考\引用{Thim05},\引用{ZalBar99}和\引用{Lyn02}）。还表明，汞抑制谷胱甘肽合成酶（一种作用于合成谷胱甘肽的酶），因此导致谷胱甘肽水平下降（我们参考\cite{Thim05},\cite{GeGe05},\cite{GeGe06}和\cite{RDeth04}）。汞还干扰卟啉途径中血红素的产生\引用{WoMaEc93}。血红素是生物能量的生产和通过P450酶解毒的能力所必需的，引用{Boy06}。本文旨在说明人体对汞暴露的反应是滞后的，即当汞对其主要解毒剂的反馈足够强时，汞人体负荷有两个平衡点：一个是正常解毒能力和低水平汞的平衡点，一个是抑制解毒能力和高水平汞的平衡点。此外，体内汞负担的少量增加可能不足以引发可观察到的神经毒性效应，但可能足以作为一种开关，通过环境暴露导致汞在体内积累，直到其毒性显现。
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英文标题：
《Bistable equilibrium points of mercury body burden》
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作者：
Houman Owhadi and Areen Boulos
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最新提交年份：
2007
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  In the last century mercury levels in the global environment have tripled as a result of increased pollution from industrial, occupational, medicinal and domestic uses \cite{BaMe03}. Glutathione is known to be the main agent responsible for the excretion of mercury (we refer to \cite{Thim05}, \cite{ZalBar99} and \cite{Lyn02}). It has also been shown that mercury inhibits glutathione synthetase (an enzyme acting in the synthesization of Glutathione), therefore leading to decreased glutathione levels   (we refer to \cite{Thim05}, \cite{GeGe05}, \cite{GeGe06} and \cite{RDeth04}). Mercury also interferes with the production of heme in the porphyrin pathway \cite{WoMaEc93}. Heme is needed for biological energy production and ability to detox organic toxins via the P450 enzymes \cite{Boy06}. The purpose of this paper is to show that body's response to mercury exposure is hysteretic, i.e. when this feedback of mercury on its main detoxifying agents is strong enough then mercury body burden has two points of equilibrium: one with normal abilities to detoxify and low levels of mercury and one with inhibited abilities to detoxify and high levels of mercury. Furthermore, a small increase of body's mercury burden may not be sufficient to trigger observable neurotoxic effects but it may be sufficient to act as a switch leading to an accumulation of mercury in the body through environmental exposure until its toxicity becomes manifest.
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PDF链接：
https://arxiv.org/pdf/q-bio/0606024