Adjuvant CMF
Risk of recurrence
Bonadonna et al. BMJ 2005; 330: 217
1976
The CMF programme
CMF vs observation
C, cyclophosphamide;M, methotrexate;F, 5-fluorouracil
First publication: Bonadonna et al. N Engl J Med 1976; 294: 405-410
Latest data
Risk of death
1976
Adjuvant tamoxifen
36%
Risk of recurrence
Risk of death
First publication: Lancet 1983; 1: 257-261
Br J Cancer 1988; 57: 608-611
Latest data
1983
NATO trial
Tamoxifen vs observation
Adjuvant anthracyclines
Risk of recurrence
First public ...