非常好的一本书，统计在制药领域的应用，有大量SAS实例。与大家分析，不得已要收取少量论坛币，因为自己需要下载其他资料

Book Specifications

• Available to Purchase
• Published: December 2009
• ISBN: 9781420074222
• eISBN: 9781420074239
• Fifth Edition
• 736 pages
• Format: Hardcover
• Size: 7" x 10"
• 180 Black and White Illustrations
  

Quick Overview

Become an expert on how to directly apply pharmaceutical statistics to scientific research and clinical evaluation. Written in an easy-to-read format and utilizing practical examples and solutions, this timely resource is a perfect guide for pharmaceutical scientists who need to report on clinical trials data.

The Fifth Edition has been updated and expanded to provide the most complete and comprehensive guide to the various statistical applications and research issues in the pharmaceutical industry, particularly clinical trials and bioequivalence studies.

Why every pharmaceutical researcher should own a copy of the Fifth Edition:
• Stay current with the most recent industry information on the modern principles and practices in statistics
• Logically determine sample size in bioequivalence and clinical trials, even for those with complicated designs
• Gain FDA acceptance of post-approval manufacturing changes quicker and easier by way of the in vitro in vivo correlation technique in the drug development process
• Fully analyze key concepts and text examples with the accompanying DVD containing SAS and Excel-based programs for step-by-step guidance
• Quickly and accurately evaluate pharmaceutical data using various regression techniques
  

Contants:

• Basic Definitions and Concepts
  
• Data Graphics
  
• Introduction to Probability: The Binomial and Normal Probability Distributions
  
• Choosing Samples
  
• Statistical Inference: Estimation and Hypothesis Testing
  
• Sample Size and Power
  
• Linear Regression and Correlation
  
• Analysis Of Variance
  
• Factorial Designs
  
• Transformations and Outliers
  
• Experimental Design in Clinical Trials
  
• Quality Control
  
• Validation
  
• Computer-Intensive Methods
  
• Nonparametric Methods
  
• Optimization Techniques and Screening Designs
  

Reviews:



Journal of Mathematical Psychology (for the Fourth Edition):"…The book is well written, and has extensive examples and illustrations….The authors have done an excellent job of linking the various statistical applications to research problems in the pharmaceutical industry."Current Engineering Practice (for the Fourth Edition):"…We really don't know any author to whom the entire community of pharmaceutical scientists and pharmacy can be so grateful as Bolton. Vastly knowledgeable in every aspect of the subject, he is able to inject vitality into the work, and with the added authorship in the person of Charles Bolton give us a work that will engage and reward everyone involved in pharmaceutical research and clinical evaluation."Steve Mitchell, Imperial College of London, London, UK (for the Fourth Edition):"…all of these chapters are well written, presenting the material in an easy to understand manner."