development of copolymers of poly(D,L-lactide) and methoxypolyethylene glycol as micellar carriers of paclitaxel
D,L-聚丙交酯和聚乙二醇单甲醚的二嵌段共聚物制备胶束装载紫杉醇的发展
introduction
paclitaxel:Cremophor ELDLPDLLADLPDLLACLPGACL: 疏水内核。聚乙二醇单甲醚:亲水壳。聚合物通过开环聚合反应制备:酯环打开,与聚乙二醇单甲醚一端的羟基相连(催化剂:辛酸亚锡)。
synthesis, preparation and characterization
biocompatibility
biodistribution
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