不一样样的时代ALK+非小细胞肺癌患者全程管理
马学真青岛市中心医院
ALK阳性晚期NSCLC
Soda et al., Nature, 448, 561-6 ()
Lee et al. Cancer, 118, 3579-86 ()
Shaw et al. J. Clin. Oncol., 27, 4247-4253 ()
Driver oncogenes
Kinase domain
ALK克制剂问世前，化疗方案效果不好ALK+患者的OS较短
ALK通路及药物发展简史
1.Dearden, et al. Ann Oncol ; 2. Gridelli, et al. Cancer Treat Rev 3. Hallberg, et al. Nat Rev Cancer ; 4. Rikova, et al. Cell ; 5. Soda, et al. Nature ; 6. American Cancer Society 7. Torre, et al. CA Cancer J Clin ; 8. Perez, et al. Lung Cancer; 9/Lancet. ;388( ...