Usually, we wish to test the hypothesis that B=B0, where B0 is some specified value of B. The Hypothesis that we are testing is called the null hypothesis H0. In order to test H0, we must calculate a test statistic.
If the value of the test statistic is an extreme one that would rarely be encountered by chance under the null, then the test does provide evidence against the null hypothesis. If this evidence is sufficiently convincing, we may decide to reject the null hypothesis that B=B0.