Bayesian Methods in Structural Bioinformatic

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收藏 2014-02-10

Author: Thomas Hamelryck , Kanti Mardia, Jesper Ferkinghoff-Borg

Series: Statistics for Biology and Health
Hardcover: 400 pages
Publisher: Springer; 2012 edition (March 26, 2012)
Language: English
ISBN-10: 364227224X
ISBN-13: 978-3642272240
This book is an edited volume, the goal of which is to provide an overview of the current state-of-the-art in statistical methods applied to problems in structural bioinformatics (and in particular protein structure prediction, simulation, experimental structure determination and analysis). It focuses on statistical methods that have a clear interpretation in the framework of statistical physics, rather than ad hoc, black box methods based on neural networks or support vector machines. In addition, the emphasis is on methods that deal with biomolecular structure in atomic detail. The book is highly accessible, and only assumes background knowledge on protein structure, with a minimum of mathematical knowledge. Therefore, the book includes introductory chapters that contain a solid introduction to key topics such as Bayesian statistics and concepts in machine learning and statistical physics.

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