Authors: | Yevgen Ryeznik, Oleksandr Sverdlov, Weng Kee Wong |
Title: | RARtool: A MATLAB Software Package for Designing Response-Adaptive Randomized Clinical Trials with Time-to-Event Outcomes |
Abstract: | Response-adaptive randomization designs are becoming increasingly popular in clinical trial practice. In this paper, we present RARtool, a user interface software developed in MATLAB for designing response-adaptive randomized comparative clinical trials with censored time-to-event outcomes. The RARtool software can compute different types of optimal treatment allocation designs, and it can simulate response-adaptive randomization procedures targeting selected optimal allocations. Through simulations, an investigator can assess design characteristics under a variety of experimental scenarios and select the best procedure for practical implementation. We illustrate the utility of our RARtool software by redesigning a survival trial from the literature. |
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Page views:: 627. Submitted: 2012-12-03. Published: 2015-08-26.
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Paper: | RARtool: A MATLAB Software Package for Designing Response-Adaptive Randomized Clinical Trials with Time-to-Event Outcomes [size=1em]Download PDF (Downloads: 571)
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Supplements: | RARtool.zip: MATLAB source package | [size=1em]Download(Downloads: 21; 1MB) | v66i01-replication.zip: MATLAB replication code for the examples in the paper | [size=1em]Download(Downloads: 19; 4KB) |
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