Sample Size Calculations in Clinical Research, Third Edition by Shein-Chung Chow and Jun Shao

English | 2017 | ISBN: 1138740985 | 522 pages | PDF | 81,3 MB

Provides]Explains how the formulae and procedures for sample size calculations can be used in a variety of clinical research and development stages

Presents]New edition contains 4 new chapters discussing emerging topings including adaptive designs, cluster randomized design, clinical trials with extremely low incidence rates, and clinical trial simulation.

Praise]"… this is a useful, comprehensive compendium of almost every possible sample size formula. The strong organization and carefully defined formulae will aid any researcher designing a study." -Biometrics

"This]Sample Size Calculations in Clinical Research, Third Edition presents statistical procedures for performing sample size calculations during various phases of clinical research and development. A comprehensive and unified presentation of statistical concepts and practical applications, this book includes a well-balanced summary of current and emerging clinical issues, regulatory requirements, and recently developed statistical methodologies for sample size calculation.