摘要翻译：
快感缺乏是人类抑郁症的主要症状之一。在两个实验背景下，研究了1%蔗糖溶液中添加0.2%香兰素的雄性小鼠在慢性社会应激下的消费，这些应激是由日常经历在激动相互作用中失败并导致抑郁的结果引起的。在第一个实验中，香草醛蔗糖溶液作为水的选择，在10天内生活在集体家庭笼子里的小鼠。然后将小鼠置于社会挫败应激中，在应激暴露期间，采用自由两瓶选择范式，给小鼠提供香兰素、蔗糖溶液和水。在另一个实验中，在暴露于社交失败应激8天后，首先给小鼠提供香草醛蔗糖溶液。熟悉香兰素蔗糖溶液的雄性在经历逆境胁迫时表现出香兰素蔗糖偏好：香兰素蔗糖溶液的消费量约占液体总消费量的70%。然而，在20天的社会应激中，小鼠每克体重的香草醛蔗糖溶液的消耗量显著低于对照组。在第二个实验中，雄性在社会失败应激8天后，与对照组相比，消耗的香兰素蔗糖溶液明显减少。在两周的测量中，有抑郁和焦虑症状的男性的香草醛蔗糖溶液的平均摄入量不到液体总消耗量的20%。每克体重的消耗量也明显低于对照组。本文讨论了实验背景对慢性应激雄性小鼠减少蔗糖溶液摄入量的快感缺乏症发展的影响。
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英文标题：
《Influence of experimental context on the development of anhedonia in
  male mice imposed to chronic social stress》
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作者：
N.P. Bondar, I.L. Kovalenko, D.F. Avgustinovich, N.N. Kudryavtseva
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最新提交年份：
2008
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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一级分类：Quantitative Biology        数量生物学
二级分类：Quantitative Methods        定量方法
分类描述：All experimental, numerical, statistical and mathematical contributions of value to biology
对生物学价值的所有实验、数值、统计和数学贡献
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英文摘要：
  Anhedonia is one of the key symptoms of depression in humans. Consumption of 1% sucrose solution supplemented with 0.2% vanillin was studied in two experimental contexts in male mice living under chronic social stress induced by daily experience of defeats in agonistic interactions and leading to development of depression. In the first experiment, vanillin sucrose solution was made available as an option of water during 10 days to mice living in group home cages. Then the mice were subjected to social defeat stress and during stress exposure they were provided with both vanillin sucrose solution and water using a free two bottles choice paradigm. In the other experiment, vanillin sucrose solution were first offered to mice after 8 days of exposure to social defeat stress. Males familiar with vanillin sucrose solution showed vanillin sucrose preference while experiencing defeat stress: consumption of vanillin sucrose solution was about 70% of total liquid consumption. However, the consumption of vanillin sucrose solution per gram of body weight in mice imposed to social stress during 20 days was significantly lower than in control males. In the second experiment, males after 8 days of social defeat stress were found to consume significantly less vanillin sucrose solution as compared with control males. On average during two weeks of measurements, vanillin sucrose solution intake was less than 20% of total liquid consumption in males with symptoms of depression and anxiety. Consumption per gram of body weight also appeared to be significantly lower than in control group. Influence of the experimental context on the development of anhedonia, which was measured by the reduction in sucrose solution intake by chronically stressed male mice, has been discussed.
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PDF链接：
https://arxiv.org/pdf/0706.1293