摘要翻译：
本研究在假设丰富的数学框架下，对帕金森病(PD)患者和对照组的全转录组血液表达数据集进行了分析。该分析指出，在许多已知或预测在帕金森病中被中断的过程中，血细胞中的差异表达。我们提示PD患者的循环血细胞可以处于PD的充分表达状态。我们提出了散发性帕金森病可能是造血干细胞/分化过程表达程序缺陷的一种假说，并建议这一研究方向值得进一步探讨。
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英文标题：
《A stem-cell ageing hypothesis on the origin of Parkinson's disease》
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作者：
Andr\'e X. C. N. Valente, Jorge A. B. Sousa, Tiago F. Outeiro, Lino
  Ferreira
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最新提交年份：
2010
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Cell Behavior        细胞行为
分类描述：Cell-cell signaling and interaction; morphogenesis and development; apoptosis; bacterial conjugation; viral-host interaction; immunology
细胞-细胞信号传导及相互作用；形态发生和发育；细胞凋亡；细菌接合；病毒-宿主相互作用；免疫学
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一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  A transcriptome-wide blood expression dataset of Parkinson's disease (PD) patients and controls was analyzed under the hypothesis-rich mathematical framework. The analysis pointed towards differential expression in blood cells in many of the processes known or predicted to be disrupted in PD. We suggest that circulating blood cells in PD patients can be in a full-blown PD-expression state. We put forward the hypothesis that sporadic PD can originate as a case of hematopoietic stem cell/differentiation process expression program defect and suggest this research direction deserves further investigation.
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PDF链接：
https://arxiv.org/pdf/1003.1993