摘要翻译：
染色质除了是所有人进入真核生物基因组的门户之外，近年来还被发现携带调节转录活性的表观遗传密码。对这一规范的详细了解与对它所调节的纤维结构的无知形成鲜明对比，建议的纤维模型中没有一个能够预测纤维的最基本量（直径、核小体线密度等）。我们通过建立一个简单的基于核小体形状的几何模型来解决这个长达30年的问题。在没有合适参数的情况下，我们预测了观察到的凝聚染色质纤维的性质（例如，它的直径为30纳米）、结构以及纤维如何随着核小体重复长度的变化而变化。我们的方法进一步将以前提出的过多模型置于一个连贯的框架内，并为染色质结构和功能之间的相互作用的详细研究打开了大门。
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英文标题：
《Nucleosome shape dictates chromatin-fiber structure》
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作者：
Martin Depken, Helmut Schiessel
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最新提交年份：
2007
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  Apart from being the gateway for all access to the eukaryotic genome, chromatin has in recent years been identified as carrying an epigenetic code regulating transcriptional activity. The detailed knowledge of this code contrasts the ignorance of the fiber structure which it regulates, and none of the suggested fiber models are capable of predicting the most basic quantities of the fiber (diameter, nucleosome line density, etc.). We address this three-decade-old problem by constructing a simple geometrical model based on the nucleosome shape alone. Without fit parameters we predict the observed properties of the condensed chromatin fiber (e.g. its 30 nm diameter), the structure, and how the fiber changes with varying nucleosome repeat length. Our approach further puts the plethora of previously suggested models within a coherent framework, and opens the door to detailed studies of the interplay between chromatin structure and function.
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PDF链接：
https://arxiv.org/pdf/0712.0973