摘要翻译：
利用详尽的Monte Carlo模拟，我们用晶格模型研究了纤维形成的动力学和机理，并将其作为温度和链数的函数。虽然这些模型充其量是肽的漫画，但我们表明，许多被认为控制纤维组装的通用特征存在于玩具模型中。该单体包含由三个字母（疏水性、极性和带电性）组成的八个珠子，在原生状态下采用紧凑的构象。纤维组装的动力学发生在三个不同的阶段。在每一个阶段，都有一连串的事件将单体和低聚物转变为有序结构。在第一个“爆发”阶段，形成不同大小的高流动性低聚物。向易聚集构象的转化发生在第二阶段的低聚物中。随着时间的推移，一个占主导地位的集群出现了，其中包含了大多数链。在最后阶段，易聚集的构象颗粒作为模板，较小的低聚物或单体可以停靠在上面，并转化为纤丝结构。Lifshitz-Slyazov生长动力学很好地描述了从超饱和溶液中结晶后阶段的总生长时间。
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英文标题：
《Probing the Mechanisms of Fibril Formation Using Lattice Models》
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作者：
Mai Suan Li, D. K. Klimov, J. E. Straub, and D. Thirumalai
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最新提交年份：
2008
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Biomolecules        生物分子
分类描述：DNA, RNA, proteins, lipids, etc.; molecular structures and folding kinetics; molecular interactions; single-molecule manipulation.
DNA、RNA、蛋白质、脂类等；分子结构与折叠动力学；分子相互作用；单分子操作。
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一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  Using exhaustive Monte Carlo simulations we study the kinetics and mechanism of fibril formation using lattice models as a function of temperature and the number of chains. While these models are, at best, caricatures of peptides, we show that a number of generic features thought to govern fibril assembly are present in the toy model. The monomer, which contains eight beads made from three letters (hydrophobic, polar, and charged), adopts a compact conformation in the native state. The kinetics of fibril assembly occurs in three distinct stages. In each stage there is a cascade of events that transforms the monomers and oligomers to ordered structures. In the first "burst" stage highly mobile oligomers of varying sizes form. The conversion to the aggregation-prone conformation occurs within the oligomers during the second stage. As time progresses, a dominant cluster emerges that contains a majority of the chains. In the final stage, the aggregation-prone conformation particles serve as a template onto which smaller oligomers or monomers can dock and undergo conversion to fibril structures. The overall time for growth in the latter stages is well described by the Lifshitz-Slyazov growth kinetics for crystallization from super-saturated solutions.
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PDF链接：
https://arxiv.org/pdf/0812.1274