摘要翻译:
我们计算了一个对正则遗传密码的双重前兆在减轻点突变影响方面的最优性,并将我们的结果与正则遗传密码的相应结果进行了比较。我们发现,所提出的前兆比规范码的最优性要小得多。我们的结果使双重前驱体是规范遗传密码进化过程中的一个中间状态的概念变得不太可能。这些发现支持了这样一个观点,即代码最优性反映了进化动力学,如果这样一个双重代码最初具有生化意义,那么它在翻译出现之前就已经出现了。
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英文标题:
《Optimality Properties of a Proposed Precursor to the Genetic Code》
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作者:
Thomas Butler and Nigel Goldenfeld
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最新提交年份:
2009
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分类信息:
一级分类:Quantitative Biology 数量生物学
二级分类:Other Quantitative Biology 其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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一级分类:Quantitative Biology 数量生物学
二级分类:Biomolecules 生物分子
分类描述:DNA, RNA, proteins, lipids, etc.; molecular structures and folding kinetics; molecular interactions; single-molecule manipulation.
DNA、RNA、蛋白质、脂类等;分子结构与折叠动力学;分子相互作用;单分子操作。
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英文摘要:
We calculate the optimality of a doublet precursor to the canonical genetic code with respect to mitigating the effects of point mutations and compare our results to corresponding ones for the canonical genetic code. We find that the proposed precursor has much less optimality than that of the canonical code. Our results render unlikely the notion that the doublet precursor was an intermediate state in the evolution of the canonical genetic code. These findings support the notion that code optimality reflects evolutionary dynamics, and that if such a doublet code originally had a biochemical significance, it arose before the emergence of translation.
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PDF链接:
https://arxiv.org/pdf/0905.2932