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2022-03-04
摘要翻译:
生物系统中的测量成为一个关注的主题,这是由于大量关于实验结果的有限重复性的报道。为了揭示这种不一致性的根源,我们把生物系统作为动力系统的一般特征进行了考察,这些动力系统不仅远离它们的化学平衡,而且在大多数情况下也远离它们的李雅普诺夫稳定状态。因此,在生物学实验中,我们观察的不是状态,而是被检验的有机体所遵循的不同轨迹。如果选择了一个可能的序列,就可以得到整个问题的一个微小的子部分,有时是以一种看似高度可重复性的方式。但是,只有知道一套完整的可能的轨迹,才知道有机体的状态。而这往往实际上是不可能的。因此,我们提出了一种不同的生物实验报告和分析框架,尊重非线性数学的观点。这种观点应该用来避免过于乐观的结果,结果必须被收回或大部分补充。增加实验程序的规格是更好地理解生物系统可能进化的路径范围的方法。它隐藏在实验协议的演化中。
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英文标题:
《Measurement in biological systems from the self-organisation point of
  view》
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作者:
Dalibor \v{S}tys, Jan Urban, Renata Rycht\'arikov\'a, Anna Zhyrova and
  Petr C\'isa\v{r}
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最新提交年份:
2015
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分类信息:

一级分类:Quantitative Biology        数量生物学
二级分类:Other Quantitative Biology        其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要:
  Measurement in biological systems became a subject of concern as a consequence of numerous reports on limited reproducibility of experimental results. To reveal origins of this inconsistency, we have examined general features of biological systems as dynamical systems far from not only their chemical equilibrium, but, in most cases, also of their Lyapunov stable states. Thus, in biological experiments, we do not observe states, but distinct trajectories followed by the examined organism. If one of the possible sequences is selected, a minute sub-section of the whole problem is obtained, sometimes in a seemingly highly reproducible manner. But the state of the organism is known only if a complete set of possible trajectories is known. And this is often practically impossible. Therefore, we propose a different framework for reporting and analysis of biological experiments, respecting the view of non-linear mathematics. This view should be used to avoid overoptimistic results, which have to be consequently retracted or largely complemented. An increase of specification of experimental procedures is the way for better understanding of the scope of paths, which the biological system may be evolving. And it is hidden in the evolution of experimental protocols.
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PDF链接:
https://arxiv.org/pdf/1502.02419
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