摘要翻译：
腹主动脉瘤(AAA)是腹主动脉的增大，如果不治疗，可能会逐渐变宽，并可能破裂，导致致命的后果。本文利用马尔可夫决策过程模型确定了一个最优处理策略。该政策是最优的质量调整生命年（QALYs）的数量，预计积累在一个病人的剩余生命。新政策考虑了现行临床政策忽视的因素（如预期寿命和年龄相关的手术死亡率）。由此产生的最优策略在结构上与当前策略不同。政策特别建议年轻的小动脉瘤患者进行手术治疗。通过仿真验证了该策略结构的鲁棒性。预期QALYs的数量有所增加，这表明AAAS患者的护理有可能得到改善。
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英文标题：
《A Markov Decision Process Model to Guide Treatment of Abdominal Aortic
  Aneurysms》
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作者：
Robert Mattila, Antti Siika, Joy Roy, Bo Wahlberg
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最新提交年份：
2016
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分类信息：

一级分类：Computer Science        计算机科学
二级分类：Systems and Control        系统与控制
分类描述：cs.SY is an alias for eess.SY. This section includes theoretical and experimental research covering all facets of automatic control systems. The section is focused on methods of control system analysis and design using tools of modeling, simulation and optimization. Specific areas of research include nonlinear, distributed, adaptive, stochastic and robust control in addition to hybrid and discrete event systems. Application areas include automotive and aerospace control systems, network control, biological systems, multiagent and cooperative control, robotics, reinforcement learning, sensor networks, control of cyber-physical and energy-related systems, and control of computing systems.
cs.sy是eess.sy的别名。本部分包括理论和实验研究，涵盖了自动控制系统的各个方面。本节主要介绍利用建模、仿真和优化工具进行控制系统分析和设计的方法。具体研究领域包括非线性、分布式、自适应、随机和鲁棒控制，以及混合和离散事件系统。应用领域包括汽车和航空航天控制系统、网络控制、生物系统、多智能体和协作控制、机器人学、强化学习、传感器网络、信息物理和能源相关系统的控制以及计算系统的控制。
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一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  An abdominal aortic aneurysm (AAA) is an enlargement of the abdominal aorta which, if left untreated, can progressively widen and may rupture with fatal consequences. In this paper, we determine an optimal treatment policy using Markov decision process modeling. The policy is optimal with respect to the number of quality adjusted life-years (QALYs) that are expected to be accumulated during the remaining life of a patient. The new policy takes into account factors that are ignored by the current clinical policy (e.g. the life-expectancy and the age-dependent surgical mortality). The resulting optimal policy is structurally different from the current policy. In particular, the policy suggests that young patients with small aneurysms should undergo surgery. The robustness of the policy structure is demonstrated using simulations. A gain in the number of expected QALYs is shown, which indicates a possibility of improved care for patients with AAAs.
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PDF链接：
https://arxiv.org/pdf/1611.02177