摘要翻译：
了解癌症的跨物种行为对于揭示癌症发生的基本机制以及在物种间转换模型系统的结果具有重要意义。对癌症最著名的种间考虑之一是佩托悖论，该悖论断言，体重差异很大的生物体预计会有差异很大程度的癌症风险，这种模式在经验中没有观察到。在这里，我们表明这一观察根本不是一个悖论，而是自然地从哺乳动物身体大小的代谢率的种间比例中得出的。我们将代谢异速测定与组织中癌症发展的进化模型联系起来，以表明癌症的等待时间与身体质量的比例，就像正常生物的寿命一样。因此，对哺乳动物的预期是，终生癌症风险与体重不变。因此，佩托的观察不是一个悖论，而是来自新陈代谢和生理学种间尺度的自然期望。这些异速变异模式对于理解寿命进化具有理论意义，对于使用较小的动物作为人类癌症的模型系统具有实际意义。
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英文标题：
《Paradox resolved: The allometric scaling of cancer risk across species》
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作者：
Christopher P. Kempes, Geoffrey B. West, John W. Pepper
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最新提交年份：
2020
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  Understanding the cross-species behavior of cancer is important for uncovering fundamental mechanisms of carcinogenesis, and for translating results of model systems between species. One of the most famous interspecific considerations of cancer is Peto's paradox, which asserts that organisms with vastly different body mass are expected to have a vastly different degree of cancer risk, a pattern that is not observed empirically. Here we show that this observation is not a paradox at all but follows naturally from the interspecific scaling of metabolic rates across mammalian body size. We connect metabolic allometry to evolutionary models of cancer development in tissues to show that waiting time to cancer scales with body mass in a similar way as normal organism lifespan does. Thus, the expectation across mammals is that lifetime cancer risk is invariant with body mass. Peto's observation is therefore not a paradox, but the natural expectation from interspecific scaling of metabolism and physiology. These allometric patterns have theoretical implications for understanding life span evolution, and practical implications for using smaller animals as model systems for human cancer.
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PDF链接：
https://arxiv.org/pdf/2011.11099