摘要翻译：
代谢率异速标度的起源是生物学中一个长期存在的问题。提出了几种解释起源的模型；然而，它们各有利弊。特别地，以前的模型只证明了异速标度的两个重要观测：标度指数的可变性和3/4次方律的优势。因此，这些模型对其有效性存在争议。在本研究中，我们提出了一个简单的几何模型，并通过结合细胞大小对代谢率的影响和类分形（分层）组织两个概念，表明细胞总表面积决定代谢率的假设可以再现这两个观察。虽然考虑了几种不同的生物策略，但所提出的模型在理论和数值上都证明了近似3/4次方定律。实证数据验证了模型的有效性。此外，该模型表明细胞大小的不均一性对于异速尺度出现的重要性。提出的模型提供了直观和独特的见解，以起源的异速标度定律在生物学，尽管该模型的一些限制。
---
英文标题：
《Heterogeneity of cells may explain allometric scaling of metabolic rate》
---
作者：
Kazuhiro Takemoto
---
最新提交年份：
2015
---
分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
--
一级分类：Physics        物理学
二级分类：Biological Physics        生物物理学
分类描述：Molecular biophysics, cellular biophysics, neurological biophysics, membrane biophysics, single-molecule biophysics, ecological biophysics, quantum phenomena in biological systems (quantum biophysics), theoretical biophysics, molecular dynamics/modeling and simulation, game theory, biomechanics, bioinformatics, microorganisms, virology, evolution, biophysical methods.
分子生物物理、细胞生物物理、神经生物物理、膜生物物理、单分子生物物理、生态生物物理、生物系统中的量子现象（量子生物物理）、理论生物物理、分子动力学/建模与模拟、博弈论、生物力学、生物信息学、微生物、病毒学、进化论、生物物理方法。
--

---
英文摘要：
  The origin of allometric scaling of metabolic rate is a long-standing question in biology. Several models have been proposed for explaining the origin; however, they have advantages and disadvantages. In particular, previous models only demonstrate either two important observations for the allometric scaling: the variability of scaling exponents and predominance of 3/4-power law. Thus, these models have a dispute over their validity. In this study, we propose a simple geometry model, and show that a hypothesis that total surface area of cells determines metabolic rate can reproduce these two observations by combining two concepts: the impact of cell sizes on metabolic rate and fractal-like (hierarchical) organization. The proposed model both theoretically and numerically demonstrates the approximately 3/4-power law although several different biological strategies are considered. The model validity is confirmed using empirical data. Furthermore, the model suggests the importance of heterogeneity of cell size for the emergence of the allometric scaling. The proposed model provides intuitive and unique insights into the origin of allometric scaling laws in biology, despite several limitations of the model.
---
PDF链接：
https://arxiv.org/pdf/1502.02689