摘要翻译:
目前还不清楚一个细胞如何设法找到一个特定的DNA序列足够快,以修复断裂的染色体通过同源重组。我建议解决方案是基于并行搜索,通过自由扩散的分子来实现,这些分子被编程为与断裂位点两侧的序列相对应的序列。
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英文标题:
《Hypothesis: Homologous recombination depends on parallel search》
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作者:
Johan Elf
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最新提交年份:
2016
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分类信息:
一级分类:Quantitative Biology 数量生物学
二级分类:Other Quantitative Biology 其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要:
It is not known how a cell manages to find a specific DNA sequence sufficiently fast to repair a broken chromosome through homologous recombination. I propose that the solution is based on a parallelized search implemented by freely diffusing molecules programmed with sequences corresponding to those flanking the break site.
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PDF链接:
https://arxiv.org/pdf/1608.06924