摘要翻译：
尽管关于序列特异性DNA共振在生物学中的作用的理论已经丰富了40多年，但缺乏已发表的证据。在这里，作者推断，对于持续的共振信号，每个基因组的振荡DNA序列的数量应该非常高，因此，不同大小的基因组重复是用作共振子的良好候选。此外，有人认为，为了使两个DNA序列共振，它们不一定是完全相同的。因此，在主序列中存在不同但具有相似共振子结构的序列。据推测，这些被命名为隐藏子的序列将在多细胞物种的基因组中富集。具体地说，嘌呤-嘧啶序列的离域电子云可以作为隐藏分子的基础。与随机序列对照相比，随后的基因组分析证实了嘌呤嘧啶隐藏物在哺乳动物、昆虫和植物的少数选定基因组中的富集。类似地，有人认为，多个碱基堆叠的氢键的假想离域质子云可以作为序列依赖的基于氢键的隐藏体。同样，也观察到了这种隐藏物的富集。提示这些丰富是支持基因组中序列特异性共振信号的第一个证据。
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英文标题：
《Possible traces of resonance signaling in the genome》
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作者：
Ivan Savelev and Max Myakishev-Rempel
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最新提交年份：
2019
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  Although theories regarding the role of sequence-specific DNA resonance in biology have abounded for over 40 years, the published evidence for it is lacking. Here, the authors reasoned that for sustained resonance signaling, the number of oscillating DNA sequences per genome should be exceptionally high and that, therefore, genomic repeats of various sizes are good candidates for serving as resonators. Moreover, it was suggested that for the two DNA sequences to resonate, they do not necessarily have to be identical. Therefore, the existence of sequences differing in the primary sequence but having similar resonating sub-structures was proposed. It was hypothesized that such sequences, named HIDERs, would be enriched in the genomes of multicellular species. Specifically, it was hypothesized that delocalized electron clouds of purine-pyrimidine sequences could serve as the basis of HIDERs. The consequent genomic analysis confirmed the enrichment of purine-pyrimidine HIDERs in a few selected genomes of mammals, an insect, and a plant, compared to randomized sequence controls. Similarly, it was suggested that hypothetical delocalized proton clouds of the hydrogen bonds of multiple stacked bases could serve as sequence-dependent hydrogen-bond-based HIDERs. Similarly, the enrichment of such HIDERs was observed. It is suggested that these enrichments are the first evidence in support of sequence-specific resonance signaling in the genome.
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PDF链接：
https://arxiv.org/pdf/1910.11507