摘要翻译：
一个健康的人脑灌注着通过脑血管层状流动的血液，为脑组织提供氧气和葡萄糖等底物。正常情况下，脑血流既受自身调节，也受代谢、化学和神经源性调节。这些机制的生理复杂性总是导致一个问题，即动脉和颅内压波动的统计特性之间的关系是什么。为了揭示脑血流动力学，我们采用复连续小波变换来确定脑外伤和自发性脑出血患者的动脉血压(ABP)和颅内压(ICP)之间的瞬时相位差。对于轻中度损伤的患者，相位差在时间上缓慢演变。然而，ICP升高的严重神经损伤与动脉和颅内压同步相关。我们用香农熵来量化ABP-ICP相位差的稳定性，并讨论该方法在评估脑血管反应性和自身调节完整性方面的临床适用性。
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英文标题：
《Phase synchronization in cerebral hemodynamics》
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作者：
Miroslaw Latka, Malgorzata Turalska, Waldemar Kolodziej, Dariusz
  Latka, Brahm Goldstein and Bruce J. West
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最新提交年份：
2004
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  A healthy human brain is perfused with blood flowing laminarly through cerebral vessels, providing brain tissue with substrates such as oxygen and glucose. Under normal conditions, cerebral blood flow is controlled by autoregulation as well as metabolic, chemical and neurogenic regulation. Physiological complexity of these mechanisms invariably leads to a question as to what are the relations between the statistical properties of arterial and intracranial pressure fluctuations. To shed new light on cerebral hemodynamics, we employ a complex continuous wavelet transform to determine the instantaneous phase difference between the arterial blood pressure (ABP) and intracranial pressure (ICP) in patients with traumatic brain injuries or spontaneous cerebral hemorrhage. For patients with mild to moderate injury, the phase difference slowly evolves in time. However, severe neurological injury with elevated ICP are herein associated with synchronization of arterial and intracranial pressure. We use Shannon entropy to quantify the stability of ABP-ICP phase difference and discuss the clinical applicability of such measure to assessment of cerebrovascular reactivity and autoregulation integrity.
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PDF链接：
https://arxiv.org/pdf/q-bio/0406026