摘要翻译:
我们介绍并讨论了一个最小的基于个人的流感动力学模型。该模型考虑了特异性免疫对病毒株的影响,但也考虑了感染性、随机性和最近文献中提出的超越免疫的短命毒株的存在。我们通过模拟表明,所得到的模型显示了病毒株在多年期间的替换,但它们的差异仍然是有限的。我们还表明,放弃这些特征中的任何一个都会导致完全不同的行为,要么导致疾病的灭绝,要么导致病毒株的增殖,要么导致它们的分歧。
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英文标题:
《A minimal stochastic model for influenza evolution》
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作者:
Francesca Tria, Michael Laessig, Luca Peliti and Silvio Franz
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最新提交年份:
2005
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分类信息:
一级分类:Quantitative Biology 数量生物学
二级分类:Populations and Evolution 种群与进化
分类描述:Population dynamics, spatio-temporal and epidemiological models, dynamic speciation, co-evolution, biodiversity, foodwebs, aging; molecular evolution and phylogeny; directed evolution; origin of life
种群动力学;时空和流行病学模型;动态物种形成;协同进化;生物多样性;食物网;老龄化;分子进化和系统发育;定向进化;生命起源
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一级分类:Physics 物理学
二级分类:Disordered Systems and Neural Networks 无序系统与
神经网络
分类描述:Glasses and spin glasses; properties of random, aperiodic and quasiperiodic systems; transport in disordered media; localization; phenomena mediated by defects and disorder; neural networks
眼镜和旋转眼镜;随机、非周期和准周期系统的性质;无序介质中的传输;本地化;由缺陷和无序介导的现象;神经网络
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一级分类:Physics 物理学
二级分类:Other Condensed Matter 其他凝聚态物质
分类描述:Work in condensed matter that does not fit into the other cond-mat classifications
在不适合其他cond-mat分类的凝聚态物质中工作
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一级分类:Quantitative Biology 数量生物学
二级分类:Other Quantitative Biology 其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要:
We introduce and discuss a minimal individual-based model for influenza dynamics. The model takes into account the effects of specific immunization against viral strains, but also infectivity randomness and the presence of a short-lived strain transcending immunity recently suggested in the literature. We show by simulations that the resulting model exhibits substitution of viral strains along the years, but that their divergence remains bounded. We also show that dropping any of these features results in a drastically different behavior, leading either to the extinction of the disease, to the proliferation of the viral strains, or to their divergence.
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PDF链接:
https://arxiv.org/pdf/q-bio/0505035