摘要翻译：
结合中间性中心性和q-模块性这两个互补的理论网络测度，揭示了酿酒酵母蛋白质-蛋白质物理相互作用网络的结构。酵母相互作用体的特征是通过少量的模块间蛋白质相互作用连接起来的定义良好的拓扑模块。如果这种模块间的拓扑连接被证明是模块间功能协调的一种形式，我们推测这种协调通常是以成对的方式发生的，而不是通过负责协调多个模块的高度枢纽蛋白发生的。基因复制和发散随机生长模型不考虑全局选择压力，不能再现相互作用体独特的非中枢中心的层次结构。
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英文标题：
《Yeast Protein Interactome Topology Provides Framework for
  Coordinated-Functionality》
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作者：
Andre X. C. N. Valente and Michael E. Cusick
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最新提交年份：
2006
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Molecular Networks        分子网络
分类描述：Gene regulation, signal transduction, proteomics, metabolomics, gene and enzymatic networks
基因调控、信号转导、蛋白质组学、代谢组学、基因和酶网络
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一级分类：Physics        物理学
二级分类：Other Condensed Matter        其他凝聚态物质
分类描述：Work in condensed matter that does not fit into the other cond-mat classifications
在不适合其他cond-mat分类的凝聚态物质中工作
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一级分类：Physics        物理学
二级分类：Statistical Mechanics        统计力学
分类描述：Phase transitions, thermodynamics, field theory, non-equilibrium phenomena, renormalization group and scaling, integrable models, turbulence
相变，热力学，场论，非平衡现象，重整化群和标度，可积模型，湍流
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一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  The architecture of the network of protein-protein physical interactions in Saccharomyces cerevisiae is exposed through the combination of two complementary theoretical network measures, betweenness centrality and `Q-modularity'. The yeast interactome is characterized by well-defined topological modules connected via a small number of inter-module protein interactions. Should such topological inter-module connections turn out to constitute a form of functional coordination between the modules, we speculate that this coordination is occurring typically in a pair-wise fashion, rather than by way of high-degree hub proteins responsible for coordinating multiple modules. The unique non-hub-centric hierarchical organization of the interactome is not reproduced by gene duplication-and-divergence stochastic growth models that disregard global selective pressures.
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PDF链接：
https://arxiv.org/pdf/q-bio/0505006