摘要翻译:
我们建立了DNA复制的动力学模型,定量描述了非洲爪蟾体外系统中胚泡中期转变前DNA复制的最新结果。该模型在一个简单的理论框架内很好地描述了大量不同的数据。这使得人们第一次能够在全基因组的基础上确定控制真核生物DNA复制程序的参数。特别是,我们确定了细胞周期中起源激活在时间和空间上的频率。虽然我们关注于特定的发育阶段,但这个模型很容易适应于描述许多其他生物的复制,包括芽殖酵母。
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英文标题:
《Kinetic model of DNA replication in eukaryotic organisms》
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作者:
John Herrick, Suckjoon Jun, John Bechhoefer, Aaron Bensimon
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最新提交年份:
2003
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分类信息:
一级分类:Physics 物理学
二级分类:Biological Physics 生物物理学
分类描述:Molecular biophysics, cellular biophysics, neurological biophysics, membrane biophysics, single-molecule biophysics, ecological biophysics, quantum phenomena in biological systems (quantum biophysics), theoretical biophysics, molecular dynamics/modeling and simulation, game theory, biomechanics, bioinformatics, microorganisms, virology, evolution, biophysical methods.
分子生物物理、细胞生物物理、神经生物物理、膜生物物理、单分子生物物理、生态生物物理、生物系统中的量子现象(量子生物物理)、理论生物物理、分子动力学/建模与模拟、博弈论、生物力学、生物信息学、微生物、病毒学、进化论、生物物理方法。
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一级分类:Quantitative Biology 数量生物学
二级分类:Other Quantitative Biology 其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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一级分类:Quantitative Biology 数量生物学
二级分类:Quantitative Methods 定量方法
分类描述:All experimental, numerical, statistical and mathematical contributions of value to biology
对生物学价值的所有实验、数值、统计和数学贡献
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英文摘要:
We formulate a kinetic model of DNA replication that quantitatively describes recent results on DNA replication in the in vitro system of Xenopus laevis prior to the mid-blastula transition. The model describes well a large amount of different data within a simple theoretical framework. This allows one, for the first time, to determine the parameters governing the DNA replication program in a eukaryote on a genome-wide basis. In particular, we have determined the frequency of origin activation in time and space during the cell cycle. Although we focus on a specific stage of development, this model can easily be adapted to describe replication in many other organisms, including budding yeast.
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PDF链接:
https://arxiv.org/pdf/physics/0101087