摘要翻译:
肽串作为一个概念已经发展了十四年。它们基本上是由含有彼此相似的肽部分和空间互补的氨基酸序列的蛋白质之间的物理相互作用而产生的各种量子态。在这项调查中,提出了更多的见解,支持肽串可能是一种生物物理现象的概念,值得进一步研究。具体地说,这些假定的肽串特性是波状干扰的能力和电流状特性。因此,未来对这些预测特征的实验验证和量化,以及这种储存在蛋白质和肽独特形状中的势能的应用,将有助于解决物理和医学中的挑战。在后一个领域,关键学科的药理学应该最根本的推进肽串方法。
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英文标题:
《Towards peptide strings pharmacology》
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作者:
Razvan Tudor Radulescu
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最新提交年份:
2019
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分类信息:
一级分类:Quantitative Biology 数量生物学
二级分类:Other Quantitative Biology 其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要:
Peptide strings have been developed as a concept for the past fourteen years. They are proposed to basically entail various quantum states engendered by the physical interactions of proteins containing peptide portions that are similar to one another and, moreover, amino acid sequences that are sterically complementary to each other. In this survey, additional insights are presented that support the notion that peptide strings are likely a biophysical phenomenon that warrants further investigations. Specifically, these putative peptide strings traits are the capacity for wave-like interferences and electric current-like properties. Therefore, future experimental validation and quantification of these predicted features as well as application of this potential energy that is stored in the distinct shapes of proteins and peptides may prove beneficial in addressing challenges in physics and medicine. Within the latter field, the key discipline of pharmacology should be most fundamentally advanced by the peptide strings approach.
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PDF链接:
https://arxiv.org/pdf/1902.06390