摘要翻译：
在本文中，我们确定并分析了建立HIV/AIDS生物医学知识基础的范式研究前沿的出现、结构和动态。对《科学网》（汤森路透）中以“艾滋病毒/艾滋病”、“人体免疫机能丧失病毒”、“艾滋病毒-1”和“后天免疫机能丧失综合症”为标识的论文进行了搜索。构建了这些论文的引文网络。然后，选取一个子网络中被引用次数最多的论文（最小被引用度为28）进行网络聚类和文本挖掘的结合，识别出范式研究前沿并分析其动态。在该子网络中确定了13个研究前沿。最大和最古老的战线与患者对疾病的临床知识有关。其中九个前沿与特定分子结构和机制的研究有关，其中两个前沿与药物的开发有关。其余的前沿与细胞水平的疾病研究有关。有趣的是，这些前沿的出现是在一段时间内连续出现的“波”中出现的，这表明范式焦点的转变。艾滋病毒/艾滋病研究中生物医学前沿的出现和演变，不仅是因为问题的要素和相互作用导致越来越专业化的社区，而且是因为这一健康问题的技术背景发生了变化，以及1993年至1995年期间艾滋病毒/艾滋病流行病学现实发生了巨大变化。
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英文标题：
《The emergence and evolution of the research fronts in HIV/AIDS research》
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作者：
David Fajardo-Ortiz, Malaquias Lopez-Cervantes, Luis Duran, Michel
  Dumontier, Miguel Lara, Hector Ochoa, and Victor M Castano
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最新提交年份：
2017
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分类信息：

一级分类：Computer Science        计算机科学
二级分类：Social and Information Networks        社会和信息网络
分类描述：Covers the design, analysis, and modeling of social and information networks, including their applications for on-line information access, communication, and interaction, and their roles as datasets in the exploration of questions in these and other domains, including connections to the social and biological sciences. Analysis and modeling of such networks includes topics in ACM Subject classes F.2, G.2, G.3, H.2, and I.2; applications in computing include topics in H.3, H.4, and H.5; and applications at the interface of computing and other disciplines include topics in J.1--J.7. Papers on computer communication systems and network protocols (e.g. TCP/IP) are generally a closer fit to the Networking and Internet Architecture (cs.NI) category.
涵盖社会和信息网络的设计、分析和建模，包括它们在联机信息访问、通信和交互方面的应用，以及它们作为数据集在这些领域和其他领域的问题探索中的作用，包括与社会和生物科学的联系。这类网络的分析和建模包括ACM学科类F.2、G.2、G.3、H.2和I.2的主题；计算应用包括H.3、H.4和H.5中的主题；计算和其他学科接口的应用程序包括J.1-J.7中的主题。关于计算机通信系统和网络协议（例如TCP/IP）的论文通常更适合网络和因特网体系结构（CS.NI）类别。
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一级分类：Computer Science        计算机科学
二级分类：Digital Libraries        数字图书馆
分类描述：Covers all aspects of the digital library design and document and text creation. Note that there will be some overlap with Information Retrieval (which is a separate subject area). Roughly includes material in ACM Subject Classes H.3.5, H.3.6, H.3.7, I.7.
涵盖了数字图书馆设计和文献及文本创作的各个方面。注意，与信息检索（这是一个单独的主题领域）会有一些重叠。大致包括ACM课程H.3.5、H.3.6、H.3.7、I.7中的材料。
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一级分类：Physics        物理学
二级分类：Physics and Society        物理学与社会
分类描述：Structure, dynamics and collective behavior of societies and groups (human or otherwise). Quantitative analysis of social networks and other complex networks. Physics and engineering of infrastructure and systems of broad societal impact (e.g., energy grids, transportation networks).
社会和团体（人类或其他）的结构、动态和集体行为。社会网络和其他复杂网络的定量分析。具有广泛社会影响的基础设施和系统（如能源网、运输网络）的物理和工程。
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一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  In this paper, we have identified and analyzed the emergence, structure and dynamics of the paradigmatic research fronts that established the fundamentals of the biomedical knowledge on HIV/AIDS. A search of papers with the identifiers "HIV/AIDS", "Human Immunodeficiency Virus", "HIV-1" and "Acquired Immunodeficiency Syndrome" in the Web of Science (Thomson Reuters), was carried out. A citation network of those papers was constructed. Then, a sub-network of the papers with the highest number of inter-citations (with a minimal in-degree of 28) was selected to perform a combination of network clustering and text mining to identify the paradigmatic research fronts and analyze their dynamics. Thirteen research fronts were identified in this sub-network. The biggest and oldest front is related to the clinical knowledge on the disease in the patient. Nine of the fronts are related to the study of specific molecular structures and mechanisms and two of these fronts are related to the development of drugs. The rest of the fronts are related to the study of the disease at the cellular level. Interestingly, the emergence of these fronts occurred in successive "waves" over the time which suggest a transition in the paradigmatic focus. The emergence and evolution of the biomedical fronts in HIV/AIDS research is explained not just by the partition of the problem in elements and interactions leading to increasingly specialized communities, but also by changes in the technological context of this health problem and the dramatic changes in the epidemiological reality of HIV/AIDS that occurred between 1993 and 1995.
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PDF链接：
https://arxiv.org/pdf/1611.05204