摘要翻译:
我在此介绍了接种疫苗后一整年中单个受试者(me)对SARS-CoV2和关注变异体(VOC)的T和B细胞免疫的纵向评估。在参加现代三期临床试验后,我在免疫前和免疫后收集了自己的生物样本,以作为实验疫苗的接受者。证据有力地支持了我没有接受安慰剂的结论。诚然,分析仅限于1的n,但结果与来自已发表作品的数据很好地吻合,并代表了尚未进行的对单个个体内疫苗引发的免疫的更全面的纵向评估之一。尽管这些数据是一个有据可查的轶事,但鉴于其粒度,它并非没有洞察力,并可能进一步用于指导未来具有实际统计意义的纵向研究。
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英文标题:
《An immunological autobiography: my year as a COVID-19 vaccine trial
participant》
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作者:
Ross M. Kedl
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最新提交年份:
2021
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分类信息:
一级分类:Quantitative Biology 数量生物学
二级分类:Other Quantitative Biology 其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要:
I present here longitudinal evaluation of T and B cell immunity to SARS-CoV2 and variants of concern (VOC) from a single subject (me) over an entire year post vaccination. After enrolling in the Moderna phase III clinical trial, I collected my own biological samples pre- and post-immunization in the event of being a recipient of the experimental vaccine. The evidence strongly supports the conclusion that I did not receive the placebo. The analysis is admittedly limited to an n of 1, but the results fit well with data taken from published works and represent one of the more comprehensive longitudinal evaluations of vaccine-elicited immunity within a single individual yet to be undertaken. Though the data amount to a well-documented anecdote, given its granularity, it is not without its insights and may be of further use in directing future longitudinal studies that have actual statistical significance.
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PDF链接:
https://arxiv.org/pdf/2111.01282