摘要翻译:
我们提出了一个统计力学分析,核小体沿着酵母DNA染色体的一个定位,作为核小体结合电位和化学电位强度的函数。我们发现核小体的二能级转换区密度很大,核小体的分布随化学势的变化经历了一个“微”一级跃迁。这些核小体开关的位置与转录因子结合位点的位置有很强的相关性。
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英文标题:
《Nucleosome Switching》
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作者:
David J. Schwab, Robijn F. Bruinsma, Joseph Rudnick, Jonathan Widom
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最新提交年份:
2007
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分类信息:
一级分类:Physics 物理学
二级分类:Soft Condensed Matter 软凝聚态物质
分类描述:Membranes, polymers, liquid crystals, glasses, colloids, granular matter
膜,聚合物,液晶,玻璃,胶体,颗粒物质
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一级分类:Physics 物理学
二级分类:Statistical Mechanics 统计力学
分类描述:Phase transitions, thermodynamics, field theory, non-equilibrium phenomena, renormalization group and scaling, integrable models, turbulence
相变,热力学,场论,非平衡现象,重整化群和标度,可积模型,湍流
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一级分类:Quantitative Biology 数量生物学
二级分类:Genomics 基因组学
分类描述:DNA sequencing and assembly; gene and motif finding; RNA editing and alternative splicing; genomic structure and processes (replication, transcription, methylation, etc); mutational processes.
DNA测序与组装;基因和基序的发现;RNA编辑和选择性剪接;基因组结构和过程(复制、转录、甲基化等);突变过程。
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英文摘要:
We present a statistical-mechanical analysis of the positioning of nucleosomes along one of the chromosomes of yeast DNA as a function of the strength of the binding potential and of the chemical potential of the nucleosomes. We find a significant density of two-level nucleosome switching regions where, as a function of the chemical potential, the nucleosome distribution undergoes a "micro" first-order transition. The location of these nucleosome switches shows a strong correlation with the location of transcription-factor binding sites.
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PDF链接:
https://arxiv.org/pdf/712.1063