本人实验动物是小型猪,模型和假手术样本量分别为7和6个,简单的统计分析用的是t-test,文章投出去后审稿意见中居然有这么一条“Comparative analysis using t-test for small samples is not adequate; the authors should perform a resampling method (e.g. Monte Carlo simulation) to deal with the small sample”, 6-7只小型猪可是大动物啊,属于小样本吗?我该如何回复呢?是argue一下呢还是换方法? 如果要用 resampling method (e.g. Monte Carlo simulation),我也不会啊,请高人指导,跪谢!!