在PLOS one 投了一篇文章：颅内多发动脉瘤破裂风险分析，69个病人，每个病人均有至少2个颅内动脉瘤，其中一个破裂出血，剩余的未破裂，所以共有69个破裂的，86个未破裂的。请问有什么统计方法分析？文章中我用的是两个独立样本T检验，但审稿专家说动脉瘤之间并非完全独立，统计方法不对。（详见下面英文）我是学临床的，对统计方法不太了解，求大神指点，谢谢！

In the data analysis section, the description of the statistical and analytical methods is insufficient. The authors mention that independent sample t-test was used. This statement alone is misleading. Why did the authors use independent sample t test if they compared ruptured and unruptured aneurysms in the same patients harboring multiple intracranial aneurysms as they indicate in the paper? The general assumption is that the independent sample t-test is used to compare two independent groups. It is not readily apparent to the reader that independent t-test can be use to compare a group mean to a particular number. Presumably this is the case here. Thus, if the authors used the independent t-test to compare the AUC of the ROC curve to the diagonal ROC line with AUC of 0.5 (the method that cannot discriminate ruptured and unruptured), the authors should clearly describe this and clarify this unique situation to the readers. In relation with this, the authors should clearly explain what the p values in the tables mean.