Government finds new emails Clinton did not hand over - Reuters

Donald Trump's size fixation - Politico

US, EU vow emissions crackdown in wake of VW scandal - Reuters

Republican presidential candidate Marco Rubio has drawn heat from Jewish groups and congressional Democrats for attending a campaign fundraiser at the home of an Adolf Hitler art collector and for doing so on Judaism's holiest day of the year.

Pope Francis, in a historic visit to the White House, issued a call to reject discrimination on Wednesday and declared that climate change is a problem "which can no longer be left to a future generation." Speaking in English on the South Lawn, the .

WASHINGTON The U.S. Defense Department has found an email chain that Hillary Clinton did not give to the State Department, the State Department said on Friday, despite her saying she had provided all work emails from her time as secretary of state.

To Donald Trump, size matters. The GOP pack leader and former reality television star constantly touts the number of attendees at his events and sometimes wildly exaggerates, an unusual habit for a presidential candidate. He also publicly attacks ...

Reuters
WASHINGTON/BRUSSELS Government regulators on both sides of the Atlantic vowed on Friday to toughen auto emissions tests in the wake of Volkswagen's (VOWG_p.DE) admission it cheated on diesel emissions, but some officials and environmentalists

LOS ANGELES, Sept 25 Police in Southern California have arrested a high school student who was caught on video appearing to strike a visually impaired classmate, before he himself was punched to the ground by another student, authorities said.

Texas Sen. Ted Cruz won the presidential straw poll at the Values Voter Summit for the third year in a row on Saturday, cementing his position as the favorite of social conservatives in the Republican presidential field.

Youngest Boston Marathon victim immortalized with statue
USA TODAY
BOSTON — When creating a bronze statue of a person, etching out the smile can be a bit problematic. But when artist Victoria Guerina set out to make the life-size statue of 8-year-old Martin Richard, — unveiled at Bridgewater State University on

Florida woman charged with felony for allegedly riding sea turtle
Reuters
Sept 26 A 20-year-old Florida woman was arrested on Saturday on suspicion of riding a sea turtle on the beach in photos that went viral on social media in early July, police said. Stephanie Moore, of Melbourne, faces a felony charge of possessing ...

Cuba's Castro slams US trade embargo at United Nations
Reuters
UNITED NATIONS Cuba's President Raul Castro, speaking at the United Nations for the first time, on Saturday hailed renewed diplomatic ties with the United States as "major progress" but slammed a U.S. trade embargo as the top obstacle to Cuba's ...

New York Times       
As Volkswagen Pushed to Be No. 1, Ambitions Fueled a Scandal
New York Times
Martin Winterkorn, Volkswagen's chief executive, took the stage four years ago at the automaker's new plant in Chattanooga, Tenn., and outlined a bold strategy. The company, he said, was in the midst of a plan to more than triple its sales in the ...

Designs for Learning Environments of the Future: International Perspectives from the Learning Sciences by Michael Jacobson
English | Feb. 19, 2010 | ISBN: 0387882782 | 296 Pages | PDF | 6 MB

Sparse meta-analysis with high-dimensional data

Meta-analysis plays an important role in summarizing and synthesizing scientific evidence derived from multiple studies. With high-dimensional data, the incorporation of variable selection into meta-analysis improves model interpretation and prediction. Existing variable selection methods require direct access to raw data, which may not be available in practical situations. We propose a new approach, sparse meta-analysis (SMA), in which variable selection for meta-analysis is based solely on summary statistics and the effect sizes of each covariate are allowed to vary among studies. We show that the SMA enjoys the oracle property if the estimated covariance matrix of the parameter estimators from each study is available. We also show that our approach achieves selection consistency and estimation consistency even when summary statistics include only the variance estimators or no variance/covariance information at all. Simulation studies and applications to high-throughput genomics studies demonstrate the usefulness of our approach.

Key words
Fixed-effects models Genomics studies Oracle property Random-effects models Variable selection Within-group sparsity

Protein sequence data arise more and more often in vaccine and infectious disease research. These types of data are discrete, high-dimensional, and complex. We propose to study the impact of protein sequences on binary outcomes using a kernel-based logistic regression model, which models the effect of protein through a random effect whose variance–covariance matrix is mostly determined by a kernel function. We propose a novel, biologically motivated, profile hidden Markov model (HMM)-based mutual information (MI) kernel.

Modeling agreement on categorical scales in the presence of random scorers

An efficient resampling method for calibrating single and gene-based rare variant association analysis in case-control studies

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Among the important scientific developments of the 20th century is the explosive growth in statistical reasoning and methods for application to studies of human health. Examples include developments in likelihood methods for inference, epidemiologic statistics, clinical trials, survival analysis, and statistical genetics. Substantive problems in public health and biomedical research have fueled the development of statistical methods, which in turn have improved our ability to draw valid inferences from data. The objective of Biostatistics is to advance statistical science and its application to problems of human health and disease, with the ultimate goal of advancing the public's health.

The ten highest cited articles from Biometrika and Biostatistics from 2013 are free to read online. Read now.

Kernel-based logistic regression model for protein sequence without vectorialization
Biostat (2015) 16 (3): 480-492 first published online December 22, 2014 doi:10.1093/biostatistics/kxu056

Bayesian partial linear model for skewed longitudinal data
Biostat (2015) 16 (3): 441-453 first published online March 19, 2015 doi:10.1093/biostatistics/kxv005
...flexible dependence structure while preserving the median zero property of the marginal residual density. For random effects models, it is not straightforward to enforce the median zero marginal error density unless we make the restrictive assumption...

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discrimination between CpG islands and random sequences using Markov chains

One way of separating 2 categories using linear sub spaces of the input space (e.g. planes for 3D inputs, lines for 2D inputs, etc.) is by dimensionality reduction:

@茅于轼:是什么阻碍了中华民族的进步？有三点特别值得注意。1）思维缺少独立性和创造性，形成盲从的羊群效应；2）待人缺少平等精神，连出家人和尚都要分等级；3）对权力的极度崇拜，有了权，财富就不在话下。大官身上是不带钱的，自有人用公款为他支付。当了领导就变成真理的化身。每句话都有人为他圆场。

新史记烈女传之邓玉娇传

湘鄂西之巴东，近有烈女出焉。此烈女非囊时夫死守寡之属，亦非旧时旌表之类，乃抗暴屠凶之女也。

盖巴东，隶属恩施州，其地偏狭，乃鄂西咽喉，神农架于其北，大巴山贯其中。土家、苗族等世守其地，宋相寇准曾为县令，将军贺龙于兹杀伐，虽然，巴东乃贫蔽之邑也。

有女邓玉娇者，正青春年少，于野三关镇充杂役，或以修脚小技苟活焉。五月十日，有该镇小吏三员，曰邓贵大、黄德智并邓姓者一，聚而饮，饮而思淫，遂至邓玉娇役作之所。斯时也，邓玉娇浣衣，而黄德智先入，见其美壮，以淫语亵，邓愠，斥其非，邓贵大醺醺继入，淫欲勃勃，见邓玉娇不从，乃大怒，出囊中钱，拍击邓女之首曰：“得非以我等无钱乎？”继之用强，扑邓女于椅，欲行奸淫。邓女强挣而起，再扑，再起再扑，邓女大怒，忽出修脚利刃，直刺其喉，黄德智大骇，前搏，邓女横刀宰之，重创黄，而随行之邓姓者，心胆俱裂，骇立而已。邓贵大酒血狼藉，未几毙，黄德智者嗷嗷待毙，而邓女掷刀于地，挽发从容报警焉。

江湖传此，以为邓玉娇者，今之烈女也。宰恶吏于当场，抒民愤于巴东，壮哉！余则谓：僻远之乡，民族之地，秦汉以降，无论流官土司，均以抚民为善策，不以暴烈残其民。土家、苗人等，民风淳朴，邓玉娇抑或苗族也——官府倘迫之太甚，则其血性发作，往往啸聚山林，所谓官逼民反，不得不反，此之谓也。邓贵大等，小镇之恶吏也，区区巴东如此，国中此辈衮衮不可胜计焉尔！纵吏残民，国祸之源也。则沪上刀客，巴东烈女之起，有何怪哉？
是为记。