A peer-reviewed, open-access publication of the
R Foundation for Statistical Computing 
Contents
Editorial 
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4
Contributed Research Articles
iotools: High-Performance I/O Tools for R 
. . . . . . . . . . . . . . . . . . . 6
IsoGeneGUI: Multiple Approaches for Dose-Response Analysis of Microarray Data
Using R 
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14
Network Visualization with 
ggplot2 . . . . . . . . . . . . . . . . . . . . . . 27
OrthoPanels: An R Package for Estimating a Dynamic Panel Model with Fixed Effects
Using the Orthogonal Reparameterization Approach 
. . . . . . . . . . . . . . . 60
The 
mosaic Package: Helping Students to ‘Think with Data’ Using R 
. . . . . . . . 77
smoof: Single- and Multi-Objective Optimization Test Functions 
. . . . . . . . . . 103
minval: An R package for MINimal VALidation of Stoichiometric Reactions 
. . . . . 114
Working with Daily Climate Model Output Data in R and the 
futureheatwaves Package 
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 124
alineR: an R Package for Optimizing Feature-Weighted Alignments and Linguistic
Distances 
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 138
Implementing a Metapopulation Bass Diffusion Model using the R Package 
deSolve . 153
MDplot: Visualise Molecular Dynamics
. . . . . . . . . . . . . . . . . . . . . 164
On Some Extensions to 
GA Package: Hybrid Optimisation, Parallelisation and Islands
Evolution 
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 187
imputeTS: Time Series Missing Value Imputation in R 
. . . . . . . . . . . . . . 207
The 
NoiseFiltersR Package: Label Noise Preprocessing in R 
. . . . . . . . . . . . 219
coxphMIC: An R Package for Sparse Estimation of Cox Proportional Hazards Models
via Approximated Information Criteria 
. . . . . . . . . . . . . . . . . . . . . 229
Update of the 
nlme Package to Allow a Fixed Standard Deviation of the Residual Error
239
EMSaov: An R Package for the Analysis of Variance with the Expected Mean Squares
and its Shiny Application 
. . . . . . . . . . . . . . . . . . . . . . . . . . . 252
GsymPoint: An R Package to Estimate the Generalized Symmetry Point, an Optimal
Cut-off Point for Binary Classification in Continuous Diagnostic Tests
. . . . . . . . 262
autoimage: Multiple Heat Maps for Projected Coordinates 
. . . . . . . . . . . . 284
Market Area Analysis for Retail and Service Locations with 
MCI . . . . . . . . . . 298
2
PSF: Introduction to R Package for Pattern Sequence Based Forecasting Algorithm 
. . 324
flan: An R Package for Inference on Mutation Models. 
. . . . . . . . . . . . . . 334
Multilabel Classification with R Package 
mlr. . . . . . . . . . . . . . . . . . . 352
Counterfactual: An R Package for Counterfactual Analysis 
. . . . . . . . . . . . 370
Retrieval and Analysis of Eurostat Open Data with the 
eurostat Package 
. . . . . . 385
PGEE: An R Package for Analysis of Longitudinal Data with High-Dimensional
Covariates
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 393
BayesBinMix: an R Package for Model Based Clustering of Multivariate Binary Data 
. 403
pdp: An R Package for Constructing Partial Dependence Plots 
. . . . . . . . . . . 421
checkmate: Fast Argument Checks for Defensive R Programming 
. . . . . . . . . 437
milr: Multiple-Instance Logistic Regression with Lasso Penalty 
. . . . . . . . . . 446
spcadjust: An R Package for Adjusting for Estimation Error in Control Charts 
. . . . 458
Weighted Effect Coding for Observational Data with 
wec . . . . . . . . . . . . . 477
Hosting Data Packages via 
drat: A Case Study with Hurricane Exposure Data 
. . . . 486