【S1】We live in a society in which the medicinal and social use of substances (drugs) is pervasive: an aspirin to quiet a headache, some wine to be sociable, coffee to get going in the morning, a cigarette for the nerves.

【S2】When do these socially acceptable and apparently constructive uses of a substance become misuses?

【S3】First of all, most substances taken in excess will produce negative effects such as poisoning or intense perceptual distortions.

【S4】（X）Repeated use of a substance can also lead to （Y）physical addiction or substance dependence.

61. （Y）Physical dependence on certain substances results from （X）________.

[A] 正确：uncontrolled consumption of them over long periods of time

合理代换

• consumption of them（消费这些物质） = use of a substance（应用这些物质）

• uncontrolled（无节制） + over long periods of time（长期） = repeated（频繁）

  
  

[B] 错误：exclusive use of them for social purposes

无中生有

Exclusive …for social purposes在“路标句”中无依据

[C] 错误：quantitative application of them to the treatment of diseases

无中生有

to the treatment of diseases在“路标句”中无依据

[D] 错误：careless employment of them for unpleasant symptoms

无中生有

careless…for unpleasant symptoms在“路标句”中无依据