书名CLINICAL TRIALS A Methodologic Perspective
Second Edition
STEVEN PIANTADOSI
Johns Hopkins School of Medicine, Baltimore, MD
目录
1 Preliminaries 1
2 Clinical Trials as Research 9
3 Why Clinical Trials Are Ethical 29
4 Contexts for Clinical Trials 65
5 Statistical Perspectives 107
6 Clinical Trials as Experimental Designs 127
7 Random Error and Bias 167
8 Objectives and Outcomes 187
9 Translational Clinical Trials 211
10 Dose-Finding Designs 223
11 Sample Size and Power 251
12 The Study Cohort 301
13 Treatment Allocation 331
14 Treatment Effects Monitoring 355
15 Counting Subjects and Events 395
16 Estimating Clinical Effects 409