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2022-03-03
摘要翻译:
生物学的进步大多依赖于后来被修正、扩展或最终被实验和其他手段驳斥的理论。理论生物学主要用来提供一个基础,以合理地检查进行生物学实验的框架,并揭示在理解上被忽视的差距。然而今天,理论生物学通常已经成为计算生物学和数学生物学的同义词。这在一定程度上可以解释为最近出现的一种倾向,即倾向于采用“数据优先”而不是“理论优先”的方法。此外,产生假说有时已经变成了程序性的,而不是理论性的。这种情况使我们的理解陷入了数据中,而数据应该从许多噪声中解脱出来。鉴于生物学和医学中许多悬而未决的问题,似乎很容易恢复纯理论在生物科学中的作用。本文提出了一种“哲学生物学”(哲学生物学),它不同于生物学哲学(哲学生物学),但又与生物学哲学(哲学生物学)完全互补,它需要通过哲学方法进行生物学研究。因此,哲学生物学将是理论生物学的转世,采用了“理论”一词的真正意义,并利用了自然科学中严肃的哲学方法的丰富传统。在明确定义了一个给定的生物学问题之后,一个philbiology调查将旨在提出一组关于该问题的经验问题,以及一类可能的解决方案。重要的是,这些问题是否可以用当前的实验范式来检验,将次于这些问题是否本质上是经验性的。philbiology调查的最终目标将是发展一个理论框架,可以引导对所定义问题的观察和/或介入实验研究。
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英文标题:
《A framework for philosophical biology》
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作者:
Sepehr Ehsani
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最新提交年份:
2016
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分类信息:

一级分类:Quantitative Biology        数量生物学
二级分类:Other Quantitative Biology        其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要:
  Advances in biology have mostly relied on theories that were subsequently revised, expanded or eventually refuted using experimental and other means. Theoretical biology used to primarily provide a basis to rationally examine the frameworks within which biological experiments were carried out and to shed light on overlooked gaps in understanding. Today, however, theoretical biology has generally become synonymous with computational and mathematical biology. This could in part be explained by a relatively recent tendency in which a "data first", rather than a "theory first", approach is preferred. Moreover, generating hypotheses has at times become procedural rather than theoretical. This situation leaves our understanding enmeshed in data, which should be disentangled from much noise. Given the many unresolved questions in biology and medicine, it seems apt to revive the role of pure theory in the biological sciences. This paper makes the case for a "philosophical biology" (philbiology), distinct from but quite complementary to philosophy of biology (philobiology), which would entail biological investigation through philosophical approaches. Philbiology would thus be a reincarnation of theoretical biology, adopting the true sense of the word "theory" and making use of a rich tradition of serious philosophical approaches in the natural sciences. A philbiological investigation, after clearly defining a given biological problem, would aim to propose a set of empirical questions, along with a class of possible solutions, about that problem. Importantly, whether or not the questions can be tested using current experimental paradigms would be secondary to whether the questions are inherently empirical or not. The final goal of a philbiological investigation would be to develop a theoretical framework that can lead observational and/or interventional experimental studies of the defined problem.
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PDF链接:
https://arxiv.org/pdf/1605.00033
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