摘要翻译：
本文研究了药物治疗对标准宿主内HIV模型的影响，假设治疗是周期性的。结果表明，在这些周期机制下，根除是可能的，我们定量地描述了成功的药物或药物组合，无论是理论上还是数值上。我们还考虑了某些优化问题，例如，由这样一个事实所驱动的，即根除应该达到对病人的可接受毒性水平。事实证明，这些优化问题可以大大简化，这使得计算最优值成为一项相当简单的任务。我们的所有结果将通过基于模型中参数值的最新知识的数值例子来说明。
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英文标题：
《Within-host HIV models with periodic antiretroviral therapy》
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作者：
Patrick De Leenheer
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最新提交年份：
2008
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  This paper investigates the effect of drug treatment on the standard within-host HIV model, assuming that therapy occurs periodically. It is shown that eradication is possible under these periodic regimes, and we quantitatively characterize successful drugs or drug combinations, both theoretically and numerically. We also consider certain optimization problems, motivated for instance, by the fact that eradication should be achieved at acceptable toxicity levels to the patient. It turns out that these optimization problems can be simplified considerably, and this makes calculations of the optima a fairly straightforward task. All our results will be illustrated by means of numerical examples based on up-to-date knowledge of parameter values in the model.
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PDF链接：
https://arxiv.org/pdf/0801.4384