摘要翻译:
最经济有效的基于血液的无创分子癌症生物标志物是基于p53表位和MUC1串联重复序列。在这里,我们使用维压缩生物信息分形标度分析来比较两种不同的、可比较的探针,它们检查了自身抗体群体的不同部分,达到了50%的联合灵敏度。我们在串联重复序列外的海洋区域发现了一个有希望的MUC1表位。
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英文标题:
《Autoantibody recognition mechanisms of MUC1》
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作者:
J. C. Phillips
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最新提交年份:
2016
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分类信息:
一级分类:Quantitative Biology 数量生物学
二级分类:Other Quantitative Biology 其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要:
The most cost-effective blood-based, noninvasive molecular cancer biomarkers are based on p53 epitopes and MUC1 tandem repeats. Here we use dimensionally compressed bioinformatic fractal scaling analysis to compare the two distinct and comparable probes, which examine different sections of the autoantibody population, achieving combined sensitivities of order 50%. We discover a promising MUC1 epitope in the SEA region outside the tandem repeats.
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PDF链接:
https://arxiv.org/pdf/1606.07024