摘要翻译：
最近，来自Craig J.Venter研究所的科学家报告了使用各种实验程序构建超长DNA分子，采用了一些有效的假设。找到一个产生如此长序列的数学规则将彻底改变我们对生物学各个先进领域的思考，即。染色体中长DNA链的进化，长段非编码区存在的原因，以及为染色体工程提供长DNA链制备的自动化方法。然而，这一数学原理必须有空间在基因组的突变和/或DNA聚合酶数百万年来引入错误的区域局部编辑/纠正DNA序列。本文介绍了L-系统（一种数学原理）的基本原理和应用，它可以解决上述问题。最后，我们给出了利用PC机的计算能力，利用这一数学原理生成的整个人类线粒体基因组。我们现在可以说，我们可以用PC计算能力制造出任何一段DNA，无论是936 bp的嗅觉受体，有没有内含子，线粒体DNA，还是整个人类基因组的3×109bp的DNA序列。
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英文标题：
《Complete Human Mitochondrial Genome Construction Using L-systems》
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作者：
Sk. Sarif Hassana, Pabitra Pal Choudhury, Amita Pal, R. L. Brahmachary
  and Arunava Goswami
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最新提交年份：
2010
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  Recently, scientists from The Craig J. Venter Institute reported construction of very long DNA molecules using a variety of experimental procedures adopting a number of working hypotheses. Finding a mathematical rule for generation of such a long sequence would revolutionize our thinking on various advanced areas of biology, viz. evolution of long DNA chains in chromosomes, reasons for existence of long stretches of non-coding regions as well as would usher automated methods for long DNA chains preparation for chromosome engineering. However, this mathematical principle must have room for editing / correcting DNA sequences locally in those areas of genomes where mutation and / or DNA polymerase has introduced errors over millions of years. In this paper, we report the basics and applications of L-system (a mathematical principle) which could answer all the aforesaid issues. At the end, we present the whole human mitochondrial genome which has been generated using this mathematical principle using PC computation power. We can claim now that we can make any stretch of DNA, be it 936 bp of olfactory receptor, with or without introns, mitochondrial DNA to 3 x 109 bp DNA sequences of the whole human genome with even a PC computation power.
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PDF链接：
https://arxiv.org/pdf/1002.3292