摘要翻译：
背景。在已知的动物基因组中，基因在染色体上的大规模分布模式还没有很好的描述。我们假设单个基因将以数学上有序的方式分布在动物界的染色体上。结果。对NCBI数据库中报告的21个动物基因组进行了检查。从数量上看，随着基因组大小的增加，总基因含量有增加的趋势，这反映在染色体补体上。分析了每种动物基因组中个体染色体上的基因频率，并证明了个体染色体上的平均基因频率和整个独特基因组上的基因分布在每种动物中的比例的均匀性。此外，动物物种间的平均基因分布遵循一种关系，即它与独特动物基因组中染色体数目的平方根近似成反比，这与随着基因组复杂性的增加，基因分散有有序增加的概念相一致。为了进一步证实这些发现，衍生出一种测量方法，称为染色体上的基因间距，与基因频率和基因分布相关。结论。随着动物物种的进化，它们的基因在单个染色体上和基因组内的分布，当从大范围来看时，并不是随机的，而是遵循一个数学上有序的过程，这样，随着有机体复杂性的增加，基因在染色体上的分布变得不那么密集，而在基因组上的分布变得更加分散。
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英文标题：
《On the Order of Gene Distribution on Chromosomes Across the Animal
  Kingdom》
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作者：
Abdullah A. Toor and Amir A. Toor MD
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最新提交年份：
2019
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  Background. The large-scale pattern of distribution of genes on the chromosomes in the known animal genomes is not well characterized. We hypothesized that individual genes will be distributed on chromosomes in a mathematically ordered manner across the animal kingdom. Results. Twenty-one animal genomes reported in the NCBI database were examined. Numerically, there was a trend towards increasing overall gene content with increasing size of the genome as reflected by the chromosomal complement. Gene frequency on individual chromosomes in each animal genome was analyzed and demonstrated uniformity of proportions within each animal with respect to both average gene frequency on individual chromosomes and gene distribution across the unique genomes. Further, average gene distribution across animal species followed a relationship whereby it was, approximately, inversely proportional to the square root of the number of chromosomes in the unique animal genomes, consistent with the notion that there is an ordered increase in gene dispersion as the complexity of the genome increased. To further corroborate these findings a derived measure, termed gene spacing on chromosomes correlated with gene frequency and gene distribution. Conclusion. As animal species have evolved, the distribution of their genes on individual chromosomes and within their genomes, when viewed on a large scale is not random, but follows a mathematically ordered process, such that as the complexity of the organism increases, the genes become less densely distributed on the chromosomes and more dispersed across the genome.
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PDF链接：
https://arxiv.org/pdf/1912.07154