摘要翻译:
人骨块的形成是为了了解潜在的动力学,着眼于骨骨折和骨不连在非侵入性途径中的愈合。成骨细胞、破骨细胞和骨细胞是形成新骨或骨物质的重要生物细胞,其中有许多激素、蛋白质和矿物质起着不可缺少的支持作用。以上述三个细胞的种群为变量,建立了一个由时间微分方程组表示的理论模型。这些方程模拟了骨物质产生的动态过程。高值骨细胞和中等水平的成骨细胞和破骨细胞,都在渐近尺度上,暗示新的骨物质在我们的模型中产生。对该模型进行了分析和数值研究。重点介绍了一些重要的结果,并进行了相关的预测,可供今后的实验检验。
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英文标题:
《Studies on Bone-mass Formation within a Theoretical Model》
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作者:
Nirmalendu Hui and Biplab Chattopadhyay
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最新提交年份:
2019
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分类信息:
一级分类:Quantitative Biology        数量生物学
二级分类:Other Quantitative Biology        其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要:
  Bone-mass formation in human is looked at to understand the underlying dynamics with an eye on healing of bone-fracture and non-unions in non-invasive pathways. Three biological cells osteoblasts, osteoclasts and osteocytes are important players in creating new bone or osseous matter in which quite a few hormones, proteins and minerals have indispensable supportive role. Assuming populations of the three mentioned cells as variables, we frame a theoretical model which is represented as a set of time differential equations. These equations imitate the dynamic process of bone matter creation. High value of osteocytes with moderate level values of osteoblast and osteoclast, all at asymptotic scale, imply creation of new bone-matter in our model. The model is studied both analytically and numerically. Some important results are highlighted and relevant predictions are made which could be put to future experimental test. 
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PDF链接:
https://arxiv.org/pdf/1906.01464