摘要翻译：
目的：本研究在某些HLA血清型的个体中寻找新型冠状病毒和疟原虫之间的共同致病性。方法:1-)Tblastx搜索新型冠状病毒，将搜索范围限制在感染人类的疟原虫种。2-）用BLASTP搜索各个生物体蛋白质组中的序列。3-）进行鉴定的新型冠状病毒肽与MHC I类超型代表的结合预测。4-）通过限制搜索人类和疟原虫物种来进行Blastp搜索与鉴定的HLA等位基因强烈结合的预测表位。5-）在结果中发现至少60%与预测表位相同的肽。6-）这些多肽中，与相同的HLA等位基因强烈结合，被预测。7-）通过限制搜索到人类重复步骤4，对于通过限制搜索到疟原虫物种而获得的肽，在步骤4中。8-）步骤5和步骤6，结果为7。结果：新型冠状病毒的CFLGYFCTCYFGLFC肽与间日疟原虫的同源性最高。其GYFCTCYFGLF和YFCTCYFGLF部分预测与HLA-A*24:02强结合。仅对与YFCTCYFGLF同源的肽获得如下结果：YYCARRFGLF、YYCHCPFGVF和YYCQQYFFLF是人类蛋白质组中潜在的HLA-A*24:02表位。在与HLA-A*24:02强结合的疟原虫蛋白质组中的FFYTFYFELF、YFVACLFILF和YFPTITFHLF肽中，只有恶性疟原虫的FFYTFYFELF与人类蛋白质组中潜在的HLA-A*24:02表位YFYLFSLELF同源。结论：与HLA-A*24:02具有较强结合亲和力的HLA-A*24:02血清型的个体在感染新型冠状病毒病毒或恶性疟原虫时，对这些序列相似的肽的免疫应答可能导致自身免疫应答的风险。
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英文标题：
《Peptides of H. sapiens and P. falciparum that are predicted to bind
  strongly to HLA-A*24:02 and homologous to a SARS-CoV-2 peptide》
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作者：
Yekbun Adiguzel
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最新提交年份：
2021
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  Aim: This study is looking for a common pathogenicity between SARS-CoV-2 and plasmodium species, in individuals with certain HLA serotypes. Methods: 1-) Tblastx searches of SARS-CoV-2 are performed by limiting searches to plasmodium species that infect human. 2-) Aligned sequences in the respective organisms' proteomes are searched with blastp. 3-) Binding predictions of the identified SARS-CoV-2 peptide to MHC class I supertype representatives are performed. 4-) Blastp searches of predicted-epitopes that bind strongly to the identified HLA allele are performed by limiting searches to human and to the plasmodium species. 5-) Peptides with minimum 60 % identity to the predicted-epitopes are found in results. 6-) Peptides among those, which bind strongly to the same HLA allele, are predicted. 7-) Step-4 is repeated by limiting searches to human, for peptides sourced by limiting searches to plasmodium species at step-4. 8-) Step-5 and 6 are performed with results of 7. Results: CFLGYFCTCYFGLFC peptide of SARS-CoV-2 has the highest identity to P. vivax. Its GYFCTCYFGLF and YFCTCYFGLF parts are predicted to bind strongly to HLA-A*24:02. Results obtained only for peptides homologous to YFCTCYFGLF, as follows: YYCARRFGLF, YYCHCPFGVF, and YYCQQYFFLF are potential HLA-A*24:02 epitopes in the human proteome. Among FFYTFYFELF, YFVACLFILF, and YFPTITFHLF peptides in the plasmodium species' proteomes with strong binding affinity to HLA-A*24:02, only FFYTFYFELF of P. falciparum is homologous to the potential HLA-A*24:02 epitope YFYLFSLELF in the human proteome. Conclusion: Immune responses to the identified-peptides with similar sequences and strong binding affinities to HLA-A*24:02 may lead to autoimmune response risk in individuals with HLA-A*24:02 serotypes, upon getting infected with SARS-CoV-2 or P. falciparum.
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PDF链接：
https://arxiv.org/pdf/2101.07356