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2022-03-06
摘要翻译:
Richard C.Lewontin可以说是20世纪下半叶最有影响力的进化生物学家。在这一章中,我提供了两个窗口关于他的有影响力的1972年的文章“人类多样性的分配”:首先,我展示了他引用的十四个出版物是如何影响他和框架他的探索;其次,我仔细阅读了这篇文章的五个部分:“介绍”、“基因”、“样本”、“多样性测量”和“结果”。我希望阐明这篇文章的基本结构和论证范围,以及它为什么成为如此具有历史意义的重要文献。特别是,我明确了所有的数学(例如,六个香农信息测度)和这个数学基础上的一般群体遗传理论(例如,瓦伦德效应)。Lewontin在他的文章中没有明确这一点。此外,在重做他的所有计算中,我发现Lewontin对他分析的所有基因都犯了计算错误(包括舍入错误或省略多样性分量值),除了一个(P),并且低估了种族间的多样性分量,甚至只是根据他自己的计算。在重现最初的计算中,我发现,种群内、种群间但小种内以及小种间多样性分配的值分别发生了轻微的变化(86%、7%、7%);这里,在Lewontin(1972)和Winther(2022)的“领域指南”中,我根据Lewontin的计算与其他统计和数据集的后续复制中产生的值来讨论这种变化。
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英文标题:
《Lewontin (1972)》
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作者:
Rasmus Gr{\o}nfeldt Winther
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最新提交年份:
2021
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分类信息:

一级分类:Quantitative Biology        数量生物学
二级分类:Other Quantitative Biology        其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要:
  Richard C. Lewontin is arguably the most influential evolutionary biologist of the second half of the 20th century. In this chapter, I provide two windows on his influential 1972 article "The Apportionment of Human Diversity": First, I show how the fourteen publications that he cites influenced him and framed his exploration; second, I present close readings of the five sections of the article: "Introduction," "The Genes," "The Samples," "The Measure of Diversity," and "The Results." I hope to illuminate the article's basic anatomy and argumentative arc, and why it became such a historically important document. In particular, I make explicit all of the mathematics (e.g., six Shannon information measures) and the general population genetic theory underlying this mathematics (e.g., the Wahlund effect). Lewontin did not make this explicit in his article. Furthermore, in redoing all of his calculations, I find that Lewontin made calculation errors (including rounding errors or omitting diversity component values) for all the genes he analyzed except one (P), and understated the among races diversity component, according to even just his own calculations. In reproducing the original computation, I find that the values of, respectively, within populations, among populations but within races, and among races diversity apportionments shift slightly (86%, 7%, 7%); here, in this "field guide" to Lewontin (1972), as well as in Winther (2022), I discuss this change in light of the values produced in subsequent replications of Lewontin's calculation with other statistics and data sets.
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PDF链接:
https://arxiv.org/pdf/2110.10945
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