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2022-03-06
摘要翻译:
什么是生活。薛定谔问题在这里讨论了一种特殊的蛋白质,绒毛蛋白,它在组织中建立细胞,检测味觉和声音。Villin由结合在肽主链上的827个氨基酸序列表示。我们把注意力集中在一个有限的问题上,从鸡到人类绒毛序列的达尔文进化。这个生物物理问题是用一种基于热力学域标度的新物理方法来分析的,这种技术跨越了物理概念、自组织临界性和传统生物结构实践之间的鸿沟。原来进化的变化可以用达尔文选择来解释,在蛋白质水平上生物学家并不普遍接受。该演示是自成一体的,不需要在分子水平上有蛋白质的经验。
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英文标题:
《Darwinian Evolution of Taste》
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作者:
J. C. Phillips
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最新提交年份:
2020
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分类信息:

一级分类:Quantitative Biology        数量生物学
二级分类:Other Quantitative Biology        其他定量生物学
分类描述:Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要:
  What is life. Schrodingers question is discussed here for a specific protein, villin, which builds cells in tissues that detect taste and sound. Villin is represented by a sequence of 827 amino acids bound to a peptide backbone chain. We focus attention on a limited problem, the Darwinian evolution of villin sequences from chickens to humans. This biophysical problem is analyzed using a new physicical method based on thermodynamic domain scaling, a technique that bridges the gap between physical concepts, self-organized criticality, and conventional biostructural practice. It turns out that the evolutionary changes can be explained by Darwinian selection, which is not generally accepted by biologists at the protein level. The presentation is self-contained, and requires no prior experience with proteins at the molecular level.
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PDF链接:
https://arxiv.org/pdf/2008.12984
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