摘要翻译：
贝壳被发现是一种非常丰富的碳酸钙自然资源。贝壳主要由文石形式的CaCO3组成，是柱状、纤维状或微球结构的晶体。本文研究了海贝纳米粒子的生物活性。收集的海贝壳被彻底清洗、干燥和粉碎。将粉末过筛并收集45至63微米范围内的颗粒。用X射线衍射和场发射扫描电镜对粉状贝壳进行了表征。XRD数据表明，颗粒主要为微球。同时也存在方解石和球面石的痕迹。采用浸泡法和干燥法对阿司匹林和雷奈酸锶药物在海贝粉中的负载进行了实验研究。在乙醇和水中配制不同浓度的药液。将贝壳粉浸泡在药物溶液中，并在间歇超声下浸泡48小时。混合物在真空炉中轻轻干燥。体外释药研究采用磷酸盐缓冲盐水。FESEM图像显示了不同大小和形状的颗粒分布。海贝壳由于其天然的孔隙率和结晶性，有望用于药物传递。阿司匹林包封率约为50%，雷奈酸锶包封率约为39%。在两个小时内观察到两种药物的突然释放（80%）。其余药物在19小时内缓慢释放。作为这项工作的一部分，还计划用无毒聚合物进一步改性海贝壳。海贝壳粉由于具有上述优点，已成为一种潜在的药物递送候选材料。
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英文标题：
《Natural calcium carbonate for biomedical applications》
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作者：
Sonali S. Sali
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最新提交年份：
2016
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分类信息：

一级分类：Quantitative Biology        数量生物学
二级分类：Other Quantitative Biology        其他定量生物学
分类描述：Work in quantitative biology that does not fit into the other q-bio classifications
不适合其他q-bio分类的定量生物学工作
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英文摘要：
  Sea shells are found to be a very rich natural resource for calcium carbonate. Sea shells are made up of CaCO3 mainly in the aragonite form, which are columnar or fibrous or microsphere structured crystals. The bioactivity of nanoparticles of sea shell has been studied in this work. The sea shells collected were thoroughly washed, dried and pulverized. The powder was sieved and particles in the range of 45 to 63 microns were collected. The powdered sea shells were characterized using X-Ray Diffraction and Field Emission Scanning Electron Microscopy. The XRD data showed that the particles were mainly microspheres. Traces of calcite and vaterite were also present. Experiments were conducted to study the aspirin and strontium ranelate drug loading into the sea shell powder using soak and dry method. Different concentrations of drug solution was made in ethanol and water. The shell powder was soaked in drug solutions and was kept soaking for 48 hrs with intermittent ultrasonication. The mixture was gently dried in a vacuum oven. The in vitro drug release studies were done using Phosphate Buffered Saline. The FESEM images displayed a distribution of differently sized and shaped particles. The sea shells due to its natural porosity and crystallinity are expected to be useful for drug delivery. About 50% drug entrapment efficiency for aspirin and 39% for strontium ranelate was seen. A burst release of the drug (80 percent) was observed within two hours for both the drugs studied. Rest of the drug was released slowly in 19 hrs. Further modification of the sea shell with non toxic polymers is also planned as a part of this work. Sea shell powder has become a potential candidate for drug delivery due to all the aforementioned advantages.
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PDF链接：
https://arxiv.org/pdf/1606.07779